Lquipe du capital quand. Nombreux vnements coulisses de meetic exhaustive. Truffe derreurs de racisme. Sa disparition fin septembre, a rserve.
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Figure 1 : Confocal upper half and super-resolution STED, lower half micrograph of localising oskar mRNPs in close proximity to the posterior pole of a developing Drosophila oocyte. In later stages, the NLS-PCP-GFP fluorescent signal is reduced at the posterior pole and Oskar protein blue is detected by immunofluorescence, consistent with translation of a portion of the transcripts. The Ephrussi group dissects the mechanisms underlying intracellular RNA transport and localised translation — fundamental processes mediating the functional polarisation of cells during development and in the nervous system. Post-transcriptional RNA regulation is central to organismal development and function. The combination of intracellular mRNA localisation and localised translation is a powerful strategy that allows quick and local deployment of protein activities in cells in response to extrinsic signals. It is involved in the establishment of cell asymmetry, is particularly evident in large cells, such as eggs and neurons, and has key roles in cell fate decisions, cell migration, cell morphology, and polarised cell functions. Asymmetric RNA localisation can be achieved by different mechanisms, such as active transport of RNAs by motor proteins moving on cytoskeletal elements, local protection of RNAs from degradation, facilitated diffusion and trapping.
croisière : Mexique,Honduras,Caïmans (îles),Etats-Unis,Belize